Associations Between the TNF-Alpha-238 Gene (rs361625) Polymorphisms and Lung Cancer: A Meta-analysis

Context: The relationship between polymorphisms in the location of cytokine tumor necrosis factor (TNF-α) and lung cancer has been investigated many studies. Accordingly, present meta-analysis study focused on TNF-α-238 gene cancer. Methods: Articles were collected from Google Scholar, Scopus, PubMed electronic databases until 2022. articles searched based keywords “Lung cancer,” “238 Gene”, “tumor factor.” selected PRISMA flow diagram. Results: There was no bias this research. Two except for two studies significantly different, while significant difference found other However, results final Overall OR with a value (0.66; 1.88) = 1.11 indicate that additive model (rs361525) SNP increases risk random (P < 0.01). Conclusions: show TNF-a-238 polymorphism allele, an effect development